Adding a certain compound to certain chemical reactions, such as: 10485-09-3, name is 2-Bromoindene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10485-09-3, Quality Control of 2-Bromoindene
n a fully dried, argon purged 100 mL reactor,JP-A-2012-206997 2. 4-g 2- (5-methyl-2-furyl) -1-indene synthesized by the method described in the publicationCharge (15.0 mmol) and 20 mL of tetrahydrofuran,n-Butyllithium solution 9.70 mL(Hexane solution, 1.55 M, 15.0 mmol) is added,Stir at room temperature for 2 hours. This reaction solution is9.00 mL (75.3 mmol) of dimethylsilyl dichloride in 10 mL of n-hexane diluted solutionAdd slowly while cooling at -78 C,Stirring was continued for 20 hours while returning to room temperature.After the solvent of the reaction solution and unreacted dimethylsilyl dichloride were distilled off, 20 mL of tetrahydrofuran and 1.50 mL (16.0 mmol) of 1,3-dimethyl-2-imidazolidinone were added to the residue.In a fully dried, argon purged 200 mL reactor, 1.45 g (59.8 mmol) of magnesium pieces are charged,Stir vigorously for 30 minutes while heating under reduced pressure.After cooling to room temperature, attach a reflux condenser,A piece of iodine and 10 mL of tetrahydrofuran were charged and stirred.After dropwise addition of 1.0 mL of a dilute solution of 2.93 g (15.0 mmol) of 2-bromoindene in 10 mL of tetrahydrofuran,Heat to reflux until the iodine color disappears in the dryer,After the reaction starts, the remaining droplets areAfter completion of the dropwise addition, the mixture was stirred at room temperature for 2 hours.This solution isAdd dropwise to the previous reaction residue dilution solution cooled to -78 C,Stirring was continued for 19 hours while slowly warming to room temperature.Add saturated aqueous ammonium chloride solution,The soluble fraction is extracted with n-hexane and the obtained fraction is saturated.Washed with Japanese salt water and dried over anhydrous magnesium sulfate.After filtering the magnesium sulfate,The residue obtained by distilling off the filtrate is purified by silica gel column chromatography,Target object shown by the following formula (A-3L)(Hereafter referred to as the compound (A-3L))Was obtained as an isomer mixture of 2.55 g (46% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoindene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Mitsui Chemicals, Inc.; Prime Polymer Co., Ltd.; Tanaka, Yoichi; Harada, Yoichi; Tamura, Naoya; Hato, Ikki; Tsuchiya, Hiroko; (55 pag.)JP2019/59724; (2019); A;,
Bromide – Wikipedia,
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