Synthetic Route of 20191-76-8, A common heterocyclic compound, 20191-76-8, name is 2,4-Dibromonaphthalen-1-amine, molecular formula is C10H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The requisite naphthols were prepared as shown in Schemes 1 – 4. Thus, 4-bromo- 2-naphthol 1 was prepared by sequential bromination, diazotisation and reduction of 1- naphthylamine according to the published procedure (M. S. Newman, V. Sankaran and D. Olson, J. Am. Chem. Soc, 1976, 98, 3237) as shown in Scheme 1.
The synthetic route of 20191-76-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D’OPTIQUE); WO2008/28930; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary