Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C14H21Br
In a 500 ml glass reaction vessel, 17.9 g (66.5 mmol) of 1-bromo-3,5-di-tert-butylbenzene,200 ml of dimethoxyethane (DME) was added,dry ice-It was cooled to -78 ¡ã C. in a methanol bath.Here, 1.65 mol / LA solution of tert-butyllithium-n-pentane80.6 ml (132 mmol)Was added dropwise,Stir for 2 hours as it was. While being cooled at -78 ¡ã C.,18.0 ml (78 mmol) of triisopropylborate was added dropwise.After the dropwise addition, the mixture was stirred for 17 hours while gradually returning to room temperature. After adding a solution of 38 g of tripotassium phosphate / 100 mL of distilled water and hydrolyzing,10.0 g (51.3 mmol) of 4-bromo-indene,1.30 g (4.96 mmol) of triphenylphosphine and 1.80 g (2.56 mmol) of dichlorobis (triphenylphosphine) palladium were successively added,After removing the low boiling fraction,And heated at 85 ¡ã C. for 6 hours.After allowing to cool, the reaction solution was poured into 100 ml of distilled water, transferred to a separating funnel and extracted with n-hexane three times, 10 ml of concentrated hydrochloric acid was added to the hexane solution at room temperature, and the mixture was stirred at room temperature for 30 minutes to obtain a palladium compound After precipitation, the mixture was filtered through filter paper, and the filtrate was washed three times with saturated brine and distilled water, and dried over sodium sulfate. The sodium sulfate was filtered, the solvent was distilled off under reduced pressure, dissolved in hexane / diisopropyl ether = 10: 1, and filtered through a silica gel column to give 4- (3,5-tert-butylphenyl) indene, 15.6 g of a pale yellow oil was obtained (yield 100percent).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 22385-77-9.
Reference:
Patent; Japan Polyethylene Corporation; Japan Polypropylene Corporation; Itagaki, Koji; Sakuragi, Tsutomu; (20 pag.)JP2015/110528; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary