Synthetic Route of 4101-68-2, These common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen atmosphere, compound 7 (1.23 g, 1.65 mmol), 1,10-dibromodecane (2.97 g, 9.9 mmol), potassium hydroxide (0.43 g, 6.6 mmol), tetrabutylammonium bromide , 0.495 mmol) was added to dichloromethane (10 ml) and water (6.5 ml), and the mixture was stirred at room temperature for 24 hours. The mixture was allowed to stand for several minutes. The aqueous layer and the organic layer were separated, and methanol (30 ml) was added to the organic layer. The precipitate was filtered and purified by silica gel column chromatography (eluent ethyl acetate / petroleum ether, volume ratio 1: 30-1: 20) to give a colorless solid (1.41 g) in 89% yield.
The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Wang, Guixia; Xia, Liting; Su, Jian; Zhang, Haifeng; (19 pag.)CN105541616; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary