Application of 50670-49-0,Some common heterocyclic compound, 50670-49-0, name is 4-Bromo-4′-methyl-1,1′-biphenyl, molecular formula is C13H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1.15; Preparation of (4-Bromo-2-methyI-2H-pyrazol-3-yl)-(4′-methyl-biphenyl-4-yl)-amine (Compound 9).A 20-mL scintillation vial was charged with 4′-bromo-4-methyl-biphenyl (247.1 mg, 1 mmol), 3-amino-4-bromo-2 -methyl pyrazole (176.0 mg, 1 mmol), sodium fert-butoxide (134.5 mg, 1.4 mmol), tris(dibenzylideneacetone)dipalladium(0) (45.8 mg, 0.05 mmol), BINAP (62.3 mg, 0.1 mmol) and toluene (2 mL) under nitrogen atmosphere. The reaction mixture was heated at 800C for 48 hours. It was then allowed to cool to room temperature, taken up in ether/ethyl acetate, filtered and concentrated. The crude material was subjected to column chromatography on silica gel (Biotage, eluent hexanes/ethyl acetate 70/30) to afford Compound 9 as a yellow solid. LCMS m/z (%) = 342 (M+H 79Br, 100), 344 (M+H 81Br, 98).
The synthetic route of 50670-49-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2006/60762; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary