Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-70-0, name is 2,4-Dimethylbromobenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H9Br
(e) (2,4-dimethyiphenyl)(phenyl)methanamine hydrochloride: To a suspension of Mg (1.32g, 55 nunol) in TI-iF (60 mnL) was added a catalytic aniount of 12 and ibrorno-2,4diniethylbenzene(0.5 g). The reaction was initiated by heating and then additional i-bromo-2,4-dimethylbenzene (8.75 g) was added dropwise. The mixture was stirred at it for 4 h under nitrogen. Benzonitrlie (5.15 g, 50 mmol) was added dropwise into the solution . After the addition, the reaction mixture was stirred at it for 16 Ii. Then the reaction was quenched by the addition 20 mL of MeOH,followed by NaBI-i, (1.9 g, 50 mniol) in portions. After stirring at rt for 5 h, the reaction was quenched by the addition of 20 nL water. Solvent was removed under reduced pressure. The residue was extracted with EtOAc (3 x 100 mE). IN aq. HCI was added to the combined organic layers during which a white solid precipitated. The white solid was collected by filtration (8.8 g, 84%). LCMS-Pi: 195 FM-NT-I2]4 IT-, = 1.232 mm. ?El NMR (500 MHz, DMSO-d6) 6 ppm9.15 (s, 2H), 7.55 (d,J 8.0 Hz, iT-i), 7.45 7.32 (in, 5Ff), 7.12 (d,.1 8.0 Hz, IT-i), 7.04 (s, iFi),5.64 5.62 (in, 1H), 2.27 (s, 3H), 2.22(s, 3H).
According to the analysis of related databases, 583-70-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary