Reference of 13633-25-5, A common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: General Procedure 3: An oven-dried 12.0 ml_ Schlenk tube containing a stirring bar was charged with the compound of formula (Ilia) (20 mol%, 16.8 mg, 0.06 mmol), L2 (10 mol%, 8.1 mg, 0.03 mmol), alkyl bromide (0.30 mmol, if solid), CF3C02Na (1.0 eq, 40.8 mg, 0.3 mmol). The schlenk tube was transferred to a nitrogen-filled glove-box where the Ni(acac)2 (10 mol%, 7.7 mg, 0.03 mmol), Na2C03 (1.0 eq, 32.0 mg, 0.30 mmol), alkyl bromide of formula R?-Br (0.30 mmol, if liquid) and anhydrous THF (0.075 M, 4ml_) were added. Then, the mixture was stirred for 1 minute and taken out of the glovebox. The Schlenk tube was placed approximately ~3 cm away from two 32 W CFL and it was rigorously stirred for 36- 96 h. After completion of the reaction, the crude material concentrated under reduced pressure. The desired product was directly purified by flash column chromatography in silica gel with pentane/EtOAc.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; FUNDACIO INSTITUT CATALA D’INVESTIGACIO QUIMICA (ICIQ); INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA); MARTIN ROMO, Ruben; SHEN, Yangyang; GU, Yiting; (56 pag.)WO2019/96832; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary