Adding a certain compound to certain chemical reactions, such as: 626-40-4, name is 3,5-Dibromoaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-40-4, Computed Properties of C6H5Br2N
This example is a method for preparing 3,5-dibromo-3-methyl-4-aminoazobenzene, comprising the following steps:(1) Preparation of diazonium salt: Into a 100 mL beaker, add 5.0132 g of 3,5-dibromoaniline and 8 mL of 20% hydrochloric acid, 0Slowly add 1.5241 g of aqueous sodium nitrite solution to the suspension at 0-5 C. The suspension is cleared and urea is added to eliminate theAmount of nitrous acid, sodium acetate solids was adjusted to pH 5, and the resulting clear solution was placed in ice water for later use.(2) Preparation of sodium o-methylanilinyl methanesulfonate: Into a 50 mL round bottom flask was added 10 mL of water and 2.3534 g of AsiaAfter dissolving sodium bisulfite and sodium bisulfite, 0.7219 g of paraformaldehyde was added. After reacting at 60C for 35 minutes, 2.1413 g of the product was added dropwise.Methylaniline, the reaction was stopped after 2 h and a mixture of sodium o-anilino methanesulfonate was obtained.(3) Preparation of azobenzene compound: After the mixture obtained in step (2) is cooled to room temperature, the mixture is stirred under vigorous stirring.Slowly dropping into the diazonium salt obtained in step (1). At this time, the clarified diazonium salt solution gradually becomes dark red viscous liquid, and the temperature is controlled at 0-5 C.The reaction was completed after 6 h. Add 50 mL of 30% aqueous sodium hydroxide, the dark red viscous liquid becomes yellow turbid liquid, nitrogen gasUnder the protection of 50 C hydrolysis 7 h, after the end of the reaction with hydrochloric acid to adjust the pH value of about 8, the crude product was separated by thin layer chromatography to obtain the dye 3,5-Dibromo-3-methyl-4-aminoazobenzene 2.1402 g (yield 30%)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromoaniline, and friends who are interested can also refer to it.
Reference:
Patent; Lingnan Normal University; Song Xiumei; Feng Zongcai; (9 pag.)CN105152963; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary