In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 314084-61-2 as follows. Recommanded Product: 2-Bromo-1,3-diethyl-5-methylbenzene
Step 2: Set up a 1000mL four-neck bottle, thermometer,Three-way nitrogen ball device, the system uses an oil pump to pump vacuum and use nitrogenAfter gas replacement for three times, under nitrogen protection,Add 100 mL of tetrahydrofuran to the system.2,6-Diethyl-4methylbromobenzene 20g (molecular weight 227.1, 0.088mol), cooled to -60 C, control the temperature of the reaction solution between -50 C and -60 C, slowly add 528 mL 1 mol / L positive Butyl lithium in n-hexane solution (0.528 mol),After the addition was completed, the temperature was kept at -50 C to -60 C for 1 h.16.49 g of 2-bromoethanol (molecular weight 124.96, 0.132 mol) was slowly added dropwise at -50 C to -60 C, and the reaction was kept after the addition.0.5h. The reaction solution was quenched with 50 mL of 1 mol/L diluted hydrochloric acid and extracted twice with 50 mL of ethyl acetate.To dryness, 16.3 g of a colorless oil was obtained. After 10 min, the oil was turned to white solid.
According to the analysis of related databases, 314084-61-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jiangsu Zhongqi Technology Co., Ltd.; Bu Long; Zhang Pu; Qian Ziwei; Gao Miao; Wang Fengyun; Hou Yuanchang; (10 pag.)CN109651068; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary