7051-34-5, name is (Bromomethyl)cyclopropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of (Bromomethyl)cyclopropane
In a round bottom flask,1 mmol of p-hydroxybenzaldehyde was added,20mL acetone dissolved,Stir evenly,3.0 mmol of potassium carbonate was added,A mixture of 1.0 equiv haloalkanes (bromomethylcyclopropane,1-bromo-3-methyl-2-butene,Bromo isobutane) in acetone solution 5 mL,The reaction was then allowed to reflux at an oil bath temperature of 65 C,The time and temperature of the reaction can be adjusted according to TLC detection,In order to carry out the reaction more thoroughly,Can be added in the middle of the reaction of 0.5equiv potassium carbonate,After the end of the reaction,First, the reaction solution was filtered under reduced pressure,The acetone solvent in the filtrate was distilled off under reduced pressure,The resulting mixture was then dissolved in methanol,Can be dissolved,Add 10 mL of the appropriate amount of saturated aqueous solution of potassium carbonate,Stirred at room temperature for 30 min,By potassium carbonate and unreacted 4-hydroxy acid esterification reaction,And then extracted with methylene chloride and saturated aqueous sodium chloride into the aqueous phase,According to the organic phase color to determine the number of extraction,Usually 3 times for the best,It is possible to remove the reaction substrate which does not participate in the reaction,The organic phase was dried with anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain an etherified product having a high purity.
The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TONGJI UNIVERSITY; WANG, HONGBING; WANG, ZHUO; (17 pag.)CN105967992; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary