Related Products of 18087-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18087-73-5, name is 3-Bromoimidazo[1,2-b]pyridazine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Compound 13 (2.5 g, 6.3 mmol) was added in 30 mL dioxane and 6 mL water, and the reaction stirred to dissolve. Then 3-bromo-imidazo [1,2-b] pyridazine (2.5 g, 12.6 mmol) , tetrakis (triphenylphosphine) palladium (0.73 g, 0.63 mmol), sodium carbonate (2.67 g, 25.2 mmol) were added into the reaction solution and refluxed under argon. The reaction was finished within 7 to 10 hours with TLC detection of the reaction progress. After cooled to room temperature, the reaction mixture was filtered through Celite, and the solvent was removal under reduced pressure and the residue was purified by column chromatography: gel (eluent petroleum ether / ethyl acetate). A pale yellow solid, yield: 65%. 1H NMR (DMSO-d6, 400 MHz, delta ppm): 9.53 (s, 1H), 8.69 (s, 1H), 8.66 (d, J = 4.4 Hz, 1H), 8.45 (s, 1H), 8.21 (dd, J = 13.8, 6.9 Hz, 2H), 7.66 (s, 1H), 7.42 (d, J = 8.4 Hz, 1H), 7.31 – 7.24 (m, 2H), 2.20 (s, 3H), 1.48 (s, 8H). ESI-MS m/z : 391.2 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromoimidazo[1,2-b]pyridazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Hu, Liming; Cao, Tingting; Lv, Yongjuan; Ding, Yiming; Yang, Leifu; Zhang, Qiang; Guo, Mingzhou; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5830 – 5835;,
Bromide – Wikipedia,
bromide – Wiktionary