Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103-64-0, name is (2-Bromovinyl)benzene, A new synthetic method of this compound is introduced below., name: (2-Bromovinyl)benzene
At room temperature under a nitrogen atmosphere, to an appropriate amount of organic solvent (volume ratio 2: a mixture of methyl tetrahydrofuran and 2-propanol 1) were added successively compound 100mmol formula (I), 170mmol compound of formula (II), (III) compounds, 20mmol composite catalyst 300mmol formula (a 6mmolPd2 (dba) 3 with 14mmol trimethylphosphine (hexafluoroacetylacetonato mixture) of copper), 10mmol 300mmol gallium trichloride and an organic base2,4-lutidine, then warmed to 85 sufficiently stirred and incubated for 4 hours;After completion of the reaction, the reaction system was filtered, and the filtrate was cooled to room temperature, and then adjusting pH to neutral, and deionized water was added and washed thoroughly shaken, and extracted 3 times with chloroform, the organic phases combined, dried over anhydrous magnesium sulfate, distillation under reduced pressure, the resulting residue was purified by column chromatography on silica gel, ethyl acetate, acetone and the like in a volume ratio of washing liquid, to afford the compound of formula (IV of), in a yield of 97.6%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Li, Naiwen; (12 pag.)CN105218553; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary