Continuously updated synthesis method about 49764-63-8

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General procedure: Furoin 2 (1.0 mmol, 192 mg) and o-phenylenediamines(1.0 mmol) were dissolved in 3mL H2O. Amberlyst-15 (100 mg)wasadded, the mixture was then heated to reflux for 10 h and cooled toroom temperature. Ethyl acetate (10 mL) was added, the organicphase was washed with water (3 x 10 mL), dried over MgSO4, andconcentrated. The crude products were purified by column chromatography,affording 3a-h and Hit-01.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Dibromobenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Ning; Yu, Zhimei; Yang, Xiaohong; Zhou, Yan; Tang, Qing; Hu, Ping; Wang, Jia; Zhang, Shao-Lin; Wang, Ming-Wei; He, Yun; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 37 – 49;,
Bromide – Wikipedia,
bromide – Wiktionary