Application of 74586-53-1, These common heterocyclic compound, 74586-53-1, name is 3-Bromo-5-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Conventional method: CDI (1.74 g, 0.01 mol) was added to dimethylacetamide solvent (1.0 mL) and were heated to 120-125C for 0.5 h. Cooled the solution to 60-65C and aniline (1.0 g, 0.01 mol) was added. After 1.5 h, HPLC analysis of the crude product showed that the reaction had proceeded to 100% conversion.The reaction solution was cooled to 20-25C and quenched with water (15 mL). The reaction mixture was extracted with isopropyl acetate (2 10 mL). The combined organic layer was washed with 1% aqueous HCl solution (2 10 mL),dried over anhydrous Na2SO4 and filtered. The filtrate was evaporated under vacuum to give 1.3 g (90%) of N-phenylacetamide (Table 2, entry 1).
The synthetic route of 74586-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chikkulapalli, Anil; Aavula, Sanjeev Kumar; Mona Np, Rifahath; Karthikeyan, Karthikeyan; Kumar C.H., Vinodh; Sulur G., Manjunatha; Sumathi, Shanmugam; Tetrahedron Letters; vol. 56; 24; (2015); p. 3799 – 3803;,
Bromide – Wikipedia,
bromide – Wiktionary