A new synthetic route of 460-00-4

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 460-00-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-00-4, name is 1-Bromo-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H4BrF

General procedure: A solution of precatalyst 2 (9.0 mg, 0.01 mmol, 1.0 mol%) in dry THF (1.5 mL) was stirred for 5 min at ambient temperature under N2. Then, bromobenzene (157 mg, 1.0 mmol) was added via syringe and the solution stirred for 5 min. Thereafter, 4-methoxyphenyl boronic acid (167 mg, 1.1 mmol) was added along with Na2CO3 (1 M (aqueous), 1 mL), and the resulting solution was stirred at 60 C for 3 h. At ambient temperature, aqueous H2O (10 mL) was added and the organic layer was extracted with EtOAc (3 x 10 mL). The combined organic layers were concentrated in vacuo and the remaining residue was purified by column chromatography (n-hexane/EtOAc: 200/1) to yield 4-Methoxybiphenyl (160 mg, 87%) as a colorless solid

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 460-00-4.

Reference:
Article; Shah, Parin; Santana, M. Dolores; Garcia, Joaquin; Serrano, J. Luis; Naik, Minal; Pednekar, Suhas; Kapdi, Anant R.; Tetrahedron; vol. 69; 5; (2013); p. 1446 – 1453;,
Bromide – Wikipedia,
bromide – Wiktionary