Reference of 61326-44-1, A common heterocyclic compound, 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, molecular formula is C26H16Br4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(3) The third step: under argon protection, add to the double-mouth bottle4,4 ‘, 4 “, 4” -tetrabromostatrene,3,4’-dimethoxydiphenylamine, palladium acetate, sodium tert-butoxide and tri-tert-butylphosphine were added, and 10 mL of toluene was added. The mixture was stirred and placed in an oil bath at 110 ¡ã C for 21 hours to stop the reaction. Saturated The ammonium chloride solution was extracted three times with dichloromethane and the organic layer was dried over anhydrous MgSO4. The crude product was subjected to silica gel column chromatography (petroleum ether: dichloromethane = 1: 2, v / v) to give a yellow solid, Methyl chloride / petroleum ether recrystallization. The product TPE-OMe-mp, the product of formula (IV):
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sun Yat-sen University; Shao Guang; Kuang Daibin; He Yanjian; Chen Jian; (17 pag.)CN105037179; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary