Sources of common compounds: 50670-49-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50670-49-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50670-49-0, name is 4-Bromo-4′-methyl-1,1′-biphenyl, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Bromo-4′-methyl-1,1′-biphenyl

The reaction mixture containing compound 3 (300 mg, 0.456 mmol,tetrahydrate), 4-methylphenylboronic acid (248 mg, 1.82 mmol), K2CO3(251 mg, 1.82 mmol), and PdCl2(PPh3)2 (38 mg, 0.055 mmol) in EtOH/H2O (5/1; 6 mL) was stirred at 50 C for 4 h under a N2 atmosphere. After cooled toroom temperature, the solution was diluted with 50 mL of EtOH and passedthorough celite and concentrated. Hexane/EtOAc (1/1) was added andextracted with water twice. To the aqueous layer, 1 M HCl was addeddropwise until the pH was approximately 2, and the resulting suspensionwas extracted twice with EtOAc. The combined organic layer was dried withNa2SO4 and passed through a short pad of silica-gel and concentrated in vacuo.To a suspension of the residue, K2CO3 (251 mg, 1.82 mmol) and Pd(PPh3)4(32 mg, 0.027 mmol) in degassed DME/H2O (9/1; 6 mL) under a N2atmosphere, bromobenzene (0.142 mL, 1.37 mmol) was added. After stirringat reflux for 6 h, the reaction solution was cooled to room temperature, dilutedwith EtOAc, and passed through celite. The filtrate was washed with water andbrine, dried with Na2SO4, and concentrated in vacuo. The residue was purifiedby silica gel column chromatography (hexane?hexane/diethylether = 98/2) togive 88 mg of 4-methyl-1,10:40,100-terphenyl (40% from 3 after 2 steps) as awhite powder. Mp: 205-207 C (lit.20a 206-208 C). The 1H and 13C NMRspectra corresponded to literature data

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50670-49-0.

Reference:
Article; Kuno, Shinichi; Kimura, Tomoyuki; Yamaguchi, Masanori; Tetrahedron Letters; vol. 55; 3; (2014); p. 720 – 724;,
Bromide – Wikipedia,
bromide – Wiktionary