Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-88-0, name is 1-Bromo-4-methylpentane, A new synthetic method of this compound is introduced below., Quality Control of 1-Bromo-4-methylpentane
General procedure: A Grignard suspension of 1-bromo-4-methylpentane in THF (50 mL) was prepared from the bromide (1.64 g, 9.94 mmol) and Mg (0.29 g, 11.92 mmol) in the usual manner. The suspension was cooled (-50 C) and Cu(I) bromide (0.712 g, 4.97 mmol) was added to it. The mixture was stirred for 15 min. To the resultant black suspension at -50 C was added compound 8a (1.5 g, 3.31 mmol) in THF (40 mL). The mixture was stirred at the same temperature for 1 h and then overnight at room temperature. The reaction was quenched by the addition of aqueous saturated NH4Cl (10 mL) and extracted with EtOAc. The organic layer was washed with 5% aqueous HCl, water, brine, and then dried over Na2SO4. Solvent removal under reduced pressure and column chromatography of the residue (silica gel, 0-10% EtOAc in hexane) afforded pure 9a (1.24 g, yield 70%) as a colorless liquid.
The synthetic route of 626-88-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dubey, Akhil Kumar; Chattopadhyay, Angshuman; Tetrahedron Asymmetry; vol. 22; 14-15; (2011); p. 1516 – 1521;,
Bromide – Wikipedia,
bromide – Wiktionary