Introduction of a new synthetic route about 418762-26-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-fluoro-5-methylaniline, other downstream synthetic routes, hurry up and to see.

Application of 418762-26-2, The chemical industry reduces the impact on the environment during synthesis 418762-26-2, name is 4-Bromo-2-fluoro-5-methylaniline, I believe this compound will play a more active role in future production and life.

Intermediate 11 2-fluoro-5-methyl-4-(l,4-dioxaspiror4.51dec-7-en-8-vl)anirine [0092] A mixture of 4,4,4,4-tetramethyl-2-(l,4-dioxaspiro[4.5]dec-7-en-8-yl)- 1,3,2-dioxaborolane (532.0 mg, 2.0 mmol), 4-bromo-2-fluoro-5-methylaniline (406.0 mg, 2.0 mmol), tetrakis(triphenylphosphine)palladium(0) (231.1 mg, 0.2 mmol), cesium fluoride (912.0 mg, 6.0 mmol), 1,2-dimethoxyethane (4 mL) and methanol (2 niL) was degassed for 5 min and then heated at 130C in a microwave reactor for 15 min. The reaction was concentrated in vacuo, and purified by silica chromatography (EtOAC / Hexanes: 3/7) to afford 2-fluoro-5-methyl-4-(l,4-dioxaspiro[4.5]dec-7-en- 8-yl)aniline; ESMS m/z 264.1 (M + H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-fluoro-5-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IRM LLC; WO2009/158431; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary