Application of 766-81-4, A common heterocyclic compound, 766-81-4, name is 3-Bromophenylacetylene, molecular formula is C8H5Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In a glove box filled with nitrogen, to an oven-dried 5 mL pressure tube equipped with a stir bar were added CuI (0.015 mmol, 2.9 mg, 0.050 equiv), 4,4′-di-tert-butyl-2,2′-dipyridine (2.0 mg, 0.0075 mmol, 0.025 equiv), azide compounds (0.36 mmol, 1.2 equiv), terminal alkynes (0.30 mmol, 1.0 equiv), (CF3CF2CO)2O (0.39 mmol, 120.9 mg, 1.3 equiv), Et3N (0.45 mmol, 45.5 mg, 1.5 equiv) and THF/n-C6H14 (1:1, 1.0 mL). The tube was sealed with Teflon screw cap and the solution was stirred at 50 C for 15 h. The reaction mixture was cooled to room temperature and was filtered through a layer of Celite, eluted with dichloromethane. The solvent was removed by rotary evaporation and the resulting product was purified by column chromatography on silica gel with n-pentane/ dichloromethane.
The synthetic route of 766-81-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lin, Bo; Wu, Wei; Weng, Zhiqiang; Tetrahedron; vol. 75; 19; (2019); p. 2843 – 2847;,
Bromide – Wikipedia,
bromide – Wiktionary