In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6274-57-3 as follows. Product Details of 6274-57-3
. Example 10. Synthesis of tributyl[{(4-dimethylamino)methyl}phenyl]stannane (S8)”BuLi To (4-bromobenzyl)dimethylamine (2.14 g, 10.0 mmol, 1.00 equiv) in Et2O (25 niL) at 23 0C was added “BuLi (2.4 M in hexane, 4.17 niL, 10 mmol, 1.0 equiv). The reaction mixture was warmed to 23 0C and stirred for 2.0 hr before the addition of “Bu3SnCl (3.25 g, 10.0 mmol, 1.00 equiv) at -78 0C. After stirring for 1.0 hr at 23 0C, the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on silica gel eluting with hexanes/EtOAc 1:1 (v/v) to afford 3.35 g of the title compound as a colorless oil (79% yield). R/= 0.20 (hexanes/EtOAc 1:1 (v/v)). NMR Spectroscopy: 1H NMR (500 MHz, CDCl3, 23 0C, delta): 7.42 (d, / = 6.5 Hz, 2H), 7.27 (d, / = 6.5 Hz, 2H), 3.41 (s, 2H), 2.26 (s,6H), 1.64-1.48 (m, 6H), 1.40-1.30 (m, 6H), 1.15-0.99 (m, 6H), 0.90 (t, / = 6.0 Hz, 9H). 13C NMR (100 MHz, CDCl3, 23 0C, delta): 140.30, 138.40, 136.36, 128.72, 64.40, 45.36, 29.07, 27.35, 13.64, 9.52. Mass Spectrometry: HRMS-FIA (m/z): Calcd for [M + H]+, 426.21772. Found, 426.21651.
According to the analysis of related databases, 6274-57-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; FURUYA, Takeru; TANG, Pingping; WO2010/59943; (2010); A2;,
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