Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13633-25-5, name is 1-Bromo-4-phenylbutane, A new synthetic method of this compound is introduced below., name: 1-Bromo-4-phenylbutane
Under nitrogen protection, p-methyliodobenzene (0.1 mmol), sodium metabisulfite (0.2 mmol, 2.0 equiv.), Tin powder (0.3 mmol, 3.0 equiv.), 1,1′-bis (diphenylphosphino) Ferrocene palladium dichloride (0.01 mmol, 10 mol%), 1,1′-bis (diphenylphosphine) ferrocene (0.02 mmol, 20 mol%), dipotassium hydrogen phosphate trihydrate (0.2 mmol, 2.0 equiv .), Tetrabutylammonium bromide (0.15 mmol, 1.5 equiv.) Was added to the reaction tube containing the magneton, and after nitrogen evacuation three times, bromophenylbutane (0.3 mmol, 3.0 equiv.) Was added, and DMSO ( 1.0mL), the reaction system was heated to 100 C for 10 hours, and the reaction was completed by spot detection. After the aryl iodide was completely converted, the reaction system was cooled to room temperature, diluted with water and added with ethyl acetate (10mL * 3) for extraction. Anhydrous sulfuric acid Sodium was dried, filtered, concentrated, and separated by column chromatography to obtain the purified target product 3ad (72%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; East China Normal University; Jiang Xuefeng; Meng Yingying; Wang Ming; (40 pag.)CN110563619; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary