These common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 149910-98-5
General procedure: To a solution of the substituted isochroman derivatives (0.5 mmol) in MeCN (1 mL), CuBr2(0.6 mmol, 134 mg) was added under nitrogen atomosphere. The solution wasrefluxed for about 1h and then cooled to room temperature. The reaction mixturewas added water, extracted with EtOAc (2 ¡Á 10 ml). The combined organicextracts were washed with brine, dried (Na2SO4), filteredand concentrated and then purified by silicagel chromatography.
The synthetic route of 7-Bromoisochroman has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhou, Mei-Yan; Kong, Shan-Shan; Zhang, Ling-Qiong; Zhao, Ming; Duan, Jin-Ao; Ou-Yang, Zhen; Wang, Min; Tetrahedron Letters; vol. 54; 30; (2013); p. 3962 – 3964;,
Bromide – Wikipedia,
bromide – Wiktionary