Reference of 103-64-0,Some common heterocyclic compound, 103-64-0, name is (2-Bromovinyl)benzene, molecular formula is C8H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of N, N-dimethylformamide (DMF) in a volume ratio of 4: 1 with polyethylene glycol 200(PEG-200)) was added 100 mmol of the compound of the above formula (I), 70 mmol of the compound of the above formula (II), 10 mmol of catalyst bis (triphenylphosphine) cyclopentadienyl ruthenium chloride,(TDI) 2), 12 mmol of organic ligand L1 and 70 mmol of base, 5,7-triazabicyclo [4.4.0] dec-5-ene (TBD), Then stirred to a temperature of 90 C, and the reaction was stirred at that temperature for 9 hours;After completion of the reaction, the reaction system is naturally cooled to room temperature and the pH is adjusted to neutral, filtered and the filtrate is saturatedSalt water washing, and then extracted with ethyl acetate 2-3 times,The combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography eluting with a 1: 2 by volume mixture of chloroform and petroleum ether to give the compound of formula (III) Was 93.9%.
The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Huang, Cheng; No proclaimed inventor; (12 pag.)CN106278839; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary