In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1003-98-1, name is 2-Bromo-4-fluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Bromo-4-fluoroaniline
Example 100:; To a DMF solution (7ml_) of 4-fluoro-2-bromoaniline (258mg, 1.36mmol) was added the alkyne 92a (400mg, 1.36mmol), Pd(PPh3)2CI2 (38mg, 0.054mmol), CuI (20.6mg, O.H mmol) and i- Pr2NH (2 mL). The mixture was degassed in vacuo, flushed with nitrogen and heated at 90C for 1 h. The resulted solution was diluted with EtOAc (3OmL), washed with brine (2x25mL), dried (MgSO4) and concentrated in vacuo. The residue was purified with silica gel column chromatography (15% EtOAc in hexanes) giving the title compound (320mg, 58% yield) as a solid. ). LCMS (APCI positive): 405 (M+H+).
The synthetic route of 1003-98-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER, INC.; WO2006/40646; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary