These common heterocyclic compound, 156682-52-9, name is 1,4-Dibromo-2,3-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1,4-Dibromo-2,3-difluorobenzene
To a fuming nitric acid (15 mL, 353.1 mmol) was added trifluoromethanesulfonic acid (40 mL, 441.4 mmol) dropwise at 0 C under argon atmosphere. A solution of compound 10 (24 g, 88.3 mmol) was added dropwise to the reaction mixture. After 24 h at 50 C, the mixture was quenched with 1 N NaOH aqueous solution. The precipitated material was recovered by filtration and then recrystallizied from ethanol to give 18 g (56%) of compound 11 as a yellow solid. 13C NMR (75 MHz, CDCl3): delta (ppm) 149.9 (dd, 1JC-F = 266.5 Hz and 2JC-F 17.3 Hz), 141.4 (br), 105.7 (dd, 2JC-F = 13.9 Hz and 3JC-F = 11.6). HRMS (m/z, EI+) calcd for C6Br2F2N2O4 359.8198, found 359.8195.
The synthetic route of 1,4-Dibromo-2,3-difluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jeong, Ina; Chae, Sangmin; Yi, Ahra; Kim, Juae; Chun, Ho Hwan; Cho, Jung Hyeong; Kim, Hyo Jung; Suh, Hongsuk; Polymer; vol. 109; (2017); p. 115 – 125;,
Bromide – Wikipedia,
bromide – Wiktionary