Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1074-24-4, name is 1,4-Dibromo-2,5-dimethylbenzene, A new synthetic method of this compound is introduced below., Formula: C8H8Br2
Under a nitrogen stream 2,5-dibromo-p-xylene (25.0 g, 94.71 mmol) is added to diethylether (350 mL), the temperature is lowered to -78 ¡ã C, and then 2.5 M n-BuLi (31.5 g, 113.6 mmol) is added slowly. After the temperature was raised to room temperature, the mixture was stirred for 1 hour, and then DMF (8.3 g, 113.65 mmol) was added slowly at -78 ¡ã C, followed by stirring at room temperature for 12 hours. To terminate the reaction, the reaction mixture is poured into water and extracted with diethylether. The organic layer is washed with MgSO4 to remove water and the solvent is removed. A white solid was obtained using a silica column (Hexane). (15.6 g, 71percent). 1H NMR (300 MHz, CDCl3, delta): 10.12(s, 1H), 7.38(s, 1H), 7.30(s, 1H), 2.35(s, 6H).
The synthetic route of 1074-24-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Korea Institute of Industrial Technology; Lee, Young Chul; Kim, Myung Jun; Kim, Baek Jin; Hwang, Suk Ho; Jung, Sung Wook; Kim, Chang Joo; (13 pag.)KR101610235; (2016); B1;,
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