Adding a certain compound to certain chemical reactions, such as: 53078-85-6, name is 2-Bromo-5-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53078-85-6, HPLC of Formula: C7H8BrN
Synthesis of Starting CompoundsPreparation of tert-butyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (A-1)Step 1: tert-butyl 2-bromo-5-methylphenylcarbamateTo a solution of 2-bromo-5-methylaniline (1.0 eq.) in tetrahydrofuran (0.2 M) at 0 C. under N2 atmosphere was added dropwise 1M NaHMDS (2.5 eq.). The reaction was stirred for 15 minutes at 0 C., and a solution of di-tert-butyl dicarbonate in tetrahydrofuran was added. The reaction was warmed to room temperature overnight. The solvent was evaporated, and the resulting residue was quenched with 0.1N HCl aqueous solution. The aqueous suspension was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The crude material was purified by flash chromatography on a COMBIFLASH system (ISCO) using 0-5% ethyl acetate in hexane to give tert-butyl 2-bromo-5-methylphenylcarbamate as a light yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; IRM LLC; Novartis AG; US2011/53893; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary