Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 452-74-4, name is 1-Bromo-2-fluoro-4-methylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 452-74-4
STEP18: Synthesis of l-Bromo-4-bromomethyl-2-fluoro-benzene; To a solution of l-Bromo-2-fluoro-4-methyl-benzene (5gm, 0.026mol) in carbon tetrachloride (40ml) N-bromosuccinimide (5.6gm, 0.037mol) was added followed by addition of 400mg of Azobisobutyro nitrile(AIBN), then after reaction mixture was refluxed for 6hrs. The reaction mixture was cooled to O0C and filtered under vacuum; filtrate was evaporated under vacuum to give 6gm of l-Bromo-4-bromomethyl-2-fluoro- benzene as yellow oil. This was further used as such.
The synthetic route of 452-74-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TORRENT PHARMACEUTICALS LTD; WO2007/100295; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary