Reference of 4101-68-2,Some common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, molecular formula is C10H20Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.23 g of compound 3, 2.97 g of 1,10-dibromodecane, 0.43 g of potassium hydroxide and 0.16 gTetrabutylammonium bromide was added to 10 ml of methylene chloride and 6.5 ml of water, and the mixture was stirred at room temperature for 24 hours under a nitrogen atmosphere.Washed twice with 30 ml of water, washed with 15 ml of saturated brine, the organic layer was separated,After drying with anhydrous sodium sulfate, the solvent was removed by rotary evaporator,Purification with 200-300 mesh silica gel column chromatography (eluent is ethyl acetate / petroleum ether, volume ratio of 1: 30-1:20) to give 1.41 g of compound 4 as a colorless solid in 89% yield
The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Zhang, Laiqi; Liao, Peihai; Wang, Guixia; (10 pag.)CN106117225; (2016); A;,
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