Related Products of 327-52-6, These common heterocyclic compound, 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
20.0 g (61.7 mmol) of (S)-3-((benzyloxycarbonyl)amino)-4-(methoxy (methyl)amino)-4-oxobutanoic acid methylester obtained in Step 1-2(3) was put in a flask filled with nitrogen, and 80 mL of dry THF was added and dissolved. 16.26 g (77 mmol) of the compound of Chemical Formula 2 was added thereto. The mixture was cooled to -10C, and 77.1 mL (154 mmol) of 2 M isopropyl magnesium chloride was added thereto over a period of 2 hours. The temperature of the mixture was raised to room temperature, and stirred for 12 hours. The reaction mixture was cooled to -10C, and 50 mL of 6N hydrochloric acid was added dropwise over a period of 2 hours. 200 mL of ethyl acetate was added for phase-separation. After phase-separation, the organic layer was washed with saturated sodium hydrogen carbonate and dried over magnesium sulfate, followed by concentration under reduced pressure to give 22 g of residual concentrate (yield 90.2%). It was used in the next step without further purification. 1H NMR(300MHz, CDCl3)delta7.65(m, 1H), 7.35(m, 5H), 6.98(m, 1H), 5.90(d, 1H), 5.18-5.08(m, 1H. s, 2H), 3.64(s, 3H), 2.97(dd, 2H)
The synthetic route of 327-52-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; CHOI, Soo Jin; LEE, Byung Goo; OH, Seong Soo; KIM, Yong Tae; EO, Jin Yong; KIM, Hung Sop; WO2012/148246; (2012); A2;,
Bromide – Wikipedia,
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