In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-40-4, name is 3,5-Dibromoaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3,5-Dibromoaniline
2-Trifluoromethylbenzoyl chloride (68.0mL, 0.462 mmol) and 3,5-dibromoaniline (96.0 mg, 0.383 mmol) were stirred in THF (2.0 mL) for 1 h.The reaction was then diluted with H2O (~20 mL) and sonicated, and the resulting precipitate was filtered, rinsed with H2O, collected, sonicated with sat. NaHCO3(~10 mL), filtered, rinsed with H2O, and collected.Flash chromatographic purification over silica (4:1-2:1 hexanes:EtOAc gradient elution) afforded 2-trifluoromethyl-N-(3,5-dibromophenyl)benzamide (216) as a white solid (143 mg, 88%).1H-NMR (500 MHz,d6-DMSO)d10.87 (s, 1H), 7.92 (d,J=1.7 Hz, 2H), 7.85-7.88 (m, 1H), 7.79-7.84 (m, 1H), 7.72-7.76 (m, 2H), 7.58 (t,J=1.7 Hz, 1H);13C-NMR (125 MHz,d6-DMSO)d166.00, 141.39, 135.26 (q,J=2.0 Hz), 132.73, 130.52, 128.53, 128.49, 126.45 (q,J=4.7 Hz), 125.85 (q,J=31.4 Hz), 123.63 (q,J=274 Hz), 122.44, 120.88; ESI-TOF 421.8996m/z[MH]+, C14H9Br2F3NO requires 421.8997; RP-HPLC: 95% pure.
The synthetic route of 626-40-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Connelly, Stephen; Mortenson, David E.; Choi, Sungwook; Wilson, Ian A.; Powers, Evan T.; Kelly, Jeffery W.; Johnson, Steven M.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3441 – 3449;,
Bromide – Wikipedia,
bromide – Wiktionary