Application of 203302-95-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 203302-95-8, name is 4-Bromo-3,5-difluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of cyclopropylamine (33 muL, 0.47 mmol) was added Et3N (200 muL, 1.41 mmol), followed by dropwise addition of acid chloride in anhydrous CH2Cl2. The solution was stirred for 2 h at room temperature, then it was washed successively with 10 % HCl, 5 % NaOH, water and brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to afford compounds 7a (85 %) as a white solid.
The synthetic route of 4-Bromo-3,5-difluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Shao-Mei; Huang, Zhi-Ning; Zhou, Zhong-Shi; Hou, Jin; Zheng, Man-Yi; Wang, Li-Juan; Jiang, Yu; Zhou, Xin-Yi; Chen, Qiu-Yue; Li, Shan-Hua; Li, Fu-Nan; Archives of Pharmacal Research; vol. 38; 10; (2015); p. 1761 – 1773;,
Bromide – Wikipedia,
bromide – Wiktionary