Electric Literature of 21524-34-5,Some common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, molecular formula is C15H23Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: An oven-dried, resealable Schlenk tube containing a stirbar was charged with aryl halide (1.0 mmol), ketone (1.1 mmol), potassium tert-butoxide (1.5 mmol), and 1 mol % catalyst, and backfilled with nitrogen. Toluene (1.5 mL) was sequentially injected, and the mixture was stirred in an oil bath at reflux temperature for the time specified. After the reaction was completed, the reaction mixture was filtered by chromatographed on silica gel and washed with EtOAc. The filtrate was dried over MgSO4 and filtered before the solvent was removed on a rotary evaporator. The pure product was obtained by preparative TLC and the yield was calculated based on ArX (the purified products were identified by comparison of melting points with the literature data or by 1H NMR and 13C NMR spectra. New compounds were determined by HRMS spectra).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,3,5-triisopropylbenzene, its application will become more common.
Reference:
Article; Zhang, Jinli; Yang, Xueqian; Cui, Xiuling; Wu, Yangjie; Tetrahedron; vol. 67; 45; (2011); p. 8800 – 8807;,
Bromide – Wikipedia,
bromide – Wiktionary