Adding a certain compound to certain chemical reactions, such as: 59907-13-0, name is 2-Bromo-1-fluoro-3-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59907-13-0, Computed Properties of C7H6BrF
[0314] To a solution of 7-isopropyl-2-methyl-3-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2- yl) -pyrazolo[l,5-a]pyrimidine-5-carboxylic acid ethyl ester (120 mg, 0.32 mmol) and 2- bromo-l-fluoro-3-methyl-benzene (60.8 mg, 0.322 mmol) in toluene (3 mL) were added Pd(PPh3)4 (37.2 mg, 0.032 mmol) and K3P04 (273.4 mg, 1.28 mmmol). The resulting mixture was bubbled with N2 for 5 mins and stirred at 130 C irridiated by microwave for 2 hrs. Then the reaction mixture was filtered, and the filtrate was concentrated in vacuum to give a residue, which was purified by a reversed-phase column (B from 5-95, A: H20, B: ACN) to afford 3-(2-fluoro-6-methyl-phenyl) -7-isopropyl-2-methyl-pyrazolo[l,5- a]pyrimidine-5-carboxylic acid ethyl ester (30.0 mg, yield: 26%) as a yellow solid. [0315] 1HNMR (400 MHz, CD3OD): delta = 7.46 (s, 1H), 7.37-7.31 (m, 1H), 7.18 (d, J = 7.6 Hz, 1H), 7.04 (t, J= 8.8 Hz, 1H), 4.44-4.39 (m, 2H), 3.96-3.92 (m, 1H), 2.37 (s, 3H), 2.14 (s, 3H), 1.51 (d, J= 6.8 Hz, 6H), 1.38 (t, J= 7.2 Hz, 3H). MS: m/z 356.2 (M+H+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-3-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; SMITH, Layton H.; PINKERTON, Anthony B.; HERSHBERGER, Paul; MALONEY, Patrick; MCANALLY, Danielle; (167 pag.)WO2019/32720; (2019); A1;,
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