Application of 393-36-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 393-36-2 as follows.
Example 89 [5-BROMO-6-TRIFLUOROMETHYL-2- [4- (3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL]-] 1H-benzoimidazole. (a) [N- [4-BROMO-3- (TRIFLUOROMETHYL)] phenyl] acetamide. A mixture [OF 4-BROMO-3- (TRIFLUOROMETHYL)] phenylamine (7.2 g, 30 mmol, Aldrich) and acetic anhydride (29 mL) was stirred at room temperature for 16 h. The reaction mixture was evaporated in vacuo to give the title product as a white solid which was used in the next step without additional purification. MS (ESI, pos. ion) [M/Z] : [484.] 0 (M+1).
According to the analysis of related databases, 393-36-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary