Adding a certain compound to certain chemical reactions, such as: 586-61-8, name is 1-Bromo-4-isopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 586-61-8, name: 1-Bromo-4-isopropylbenzene
1.07 g of 0.01 mol of 3-methylaniline, 1.98 g of 0.01 mol of 4-bromoisopropylbenzene, and 3.1 g of sodium t-butoxide were added to a 100 ml three-necked flask, dissolved in 30 ml of toluene solution, and then 0.1 g of pd2 was added under nitrogen atmosphere. (dba) 3, 0.67 g of 10% tri-tert-butylphosphine, heating at 10 C, stirring for 3 hours, the reaction is complete, adding 25 ml of toluene, 25 ml of water, liquid separation, adding the organic phase column to silica gel spin-drying, column chromatography (solvent Ethyl acetate / petroleum ether = 1:20),The column was spun dry to give 1.7 g of white intermediate A2-1, yield 76%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-isopropylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Tian Lei; Ren Xueyan; Zhang Xianghui; (35 pag.)CN108129431; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary