Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-N1-methylbenzene-1,2-diamine
Step C: 7-Bromo-1-methylquinoxaline-2,3(1H,4H)-dione Under a protection of nitrogen, to 5-bromo-N-1-methylbenzene-1,2-diamine (7.7g, 38.3mmol) and triethylamine (9.69g, 95.75mmol) in 1,2-dichloroethane (80 mL) was added oxalyl chloride monoethyl ester (6.27g, 45.96mmol) at 0C. It was stirred at 25C for 2 hours. The temperature was raised to 60C for stirring for 3 hours. The reaction solution was filtered, and the filter cake was washed twice with water (20mL). The filter cake was dried to give the title compound. 1H NMR (400MHz, DMSO-d6) delta=12.07 (br. s., 1H), 7.51 (d, J=1.2 Hz, 1H), 7.33 (dd, J=1.6, 8.2 Hz, 1H), 7.07 (d, J=8.6 Hz, 1H), 3.47 (s, 3H).
The synthetic route of 337915-79-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; LIU, Shilan; LIANG, Guibai; WANG, Hongjian; ZHANG, Ming; CHEN, Shuhui; (93 pag.)EP3640247; (2020); A1;,
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