Related Products of 51437-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51437-00-4, name is 4-Bromo-1-fluoro-2-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-Bromo-2-bromomethyI-l-fluoro-benzene (TJA01131) C7H5Br2F MW 267.92. 5-bromo-2-fluorotoluene (5.00 g, 26.5 mmol), N-bromosuccinimide (5.18 g, 29.1 mmol), benzyl peroxide (0.205 gs 0.850 mmol) and carbon tetrachloride (50 mL) were loaded to a -r.b. flask and set to reflux (79 0C) for 2 h. Once cooled the succinimide was filtered off and carbon tetrachloride removed via a dry ice-acetone cooled rotary evaporator. The residues were dissolved in dichloromethane (100 mL) and washed with distilled H2O (50 mL x 3) and brine (50 mL). Dried over MgSO4 and solvent removed in vacuo to yield the title compound as a colourless liquid yellow (6.80 g, 96 %), R/. 0.55 (dichloromethane/hexane 10:90), c.f. 0.79 (5-bromo-2-fluorotoluene); HPLC (70 % CH3CN in H2O) tr=4.786 (71.55 %).
The synthetic route of 4-Bromo-1-fluoro-2-methylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; STERIX LIMITED; WO2007/68905; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary