Application of 67567-26-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67567-26-4 as follows.
To 4-bromo-2,6-difluoroaniline (1.0 g, 4.81 mmol) and copper (I) cyanide (1.28 g, 14.3 mmol) was added DMF (10 mL) under nitrogen and the resulting mixture was heated at 160 C for 18 h. After 18 h, the mixture was cooled, poured onto a 12% aqueous ammonia solution and extracted with EtOAc (2X). The combined organic extract was washed with water. The organic phase was combined with a little water and was filtered through celite to remove suspended solids. The organic phase was then separated from the water, then washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by flash chromatography (12% EtOAc/ hexanes eluent) provided 4-amino-3,5-difluorobenzonitrile as a white solid. 1H NMR (300 MHz, Chloroform-d) delta 7.19 – 7.14 (m, 2H), 4.29 (br. s, 2H).
According to the analysis of related databases, 67567-26-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF HAWAII; TURKSON, James; YUE, Peibin; TIUS, Marcus; BROTHERTON-PLEISS, Christine; LOPEZ TAPIA, Francisco, Javier; (420 pag.)WO2018/136935; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary