Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39478-78-9, name is 5-Bromo-2-methylaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8BrN
Example 1; Preparation of (1RS.2SR.6RS.7Sf?)-4-(4′-chloro-4-methylbiphen-3-yl)-10- oxatricyclof5.2.1.02’6ldec-8-ene-3.5-dione.; Step 1 : Preparation of 3-amino-4′-chloro-4-methylbiphenyl.; Tetrakis(triphenylphosphine)palladium (0) (3.7 g, 3 mmol) and 4-chlorophenylboronic acid (20.2 g, 0.13 mol) are added to a solution of 5-bromo-2-methylaniline (20 g, 0.1 mol) in 1 ,2-dimethoxy- ethane (200 ml). After stirring the reaction mixture for 15 minutes at 20 0C, a solution of 20% aqueous sodium carbonate (300 ml) is added to the mixture, and the resulting mixture is refluxed for 24 hours. The reaction mixture is cooled to room temperature, diluted with water (600 ml) and extracted using ethyl acetate. The combined organic extracts are dried over anhydrous sodium sulfate, filtered and the filtrate evaporated under reduced pressure. The residue is further purified by column chromatography on silica gel, eluting with 7% ethyl acetate in hexane to give 3-amino- 4′-chloro-4-methylbiphenyl.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SYNGENTA LIMITED; WO2009/19015; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary