Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2924-09-6, name is 5-Bromo-2-fluoroaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5BrFN
To a solution of 5-bromo-2-fluoroaniline (1 g, 5.26 mmol) in L/,L/?-dimethylformamide (10 ml), potassium iodide (2.18 g, 13.1 mmol), and sodium carbonate (1 .95 g, 18.4 mmol) were added and the reaction mixture was heated to 150 C. Then 1 -bromo-2-(2-bromoethoxy)ethane (1.34 g, 5.77 mmol) was added and heating was continued for 16 h. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with water (25 mL) and extracted with ethyl acetate (2 x 15 mL). The combined organic extracts were dried over Na2S04, filtered and concentrated under reduced pressure to yield the crude product. The crude material was purified by flash column chromatography using hexane/ ethyl acetate (80:20) to afford the title compound (0.8 g, 58%).1H-NMR (400 MHz, CDCI3) d = 7.03-7.04 (m, 2H), 6.90-6.92 (m, 1 H), 3.87-3.88 (m, 4H), 3.08-3.10 (m, 4H).
The synthetic route of 2924-09-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (0 pag.)WO2019/233883; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary