These common heterocyclic compound, 2695-48-9, name is 8-Bromo-1-octene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H15Br
General procedure: To a vigorously stirred mixture of tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (47), (0.2 g, 1.0 mmol), bromide 48-49 (2.0 mmol) or mesylate (51, 2.00 mmol) and TBAB (32.2 mg, 0.1 mmol) in toluene (1.5 mL) were added. KOH (solid, 0.5 g, excess) was added in one portion and stirring was continued at 20C for 30 min. The mixture was then diluted with DCM (5 mL) and poured into water (5 mL). Organic phases were separated and water phase was extracted with DCM (2×5 mL). Combined organic extracts were concentrated Purification of the crude product by column chromatography on silica gel using ethyl acetate/petroleum ether mixture as an eluant afforded ethers 56-59.
The synthetic route of 8-Bromo-1-octene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bello, Claudia; Bai, Jianfei; Zambron, Bartosz K.; Elias-Rodriguez, Pilar; Gajate, Consuelo; Robina, Inmaculada; Caffa, Irene; Cea, Michele; Montecucco, Fabrizio; Nencioni, Alessio; Nahimana, Aimable; Aubry, Dominique; Breton, Caroline; Duchosal, Michel A.; Mollinedo, Faustino; Vogel, Pierre; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 457 – 478;,
Bromide – Wikipedia,
bromide – Wiktionary