Synthetic Route of 70733-25-4,Some common heterocyclic compound, 70733-25-4, name is 3-Bromo-5-methylbenzene-1,2-diamine, molecular formula is C7H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A: 3-bromo-5-methylbenzene-1,2-diamine (2.63 g, 13.1 mmol) was dissolved in a 1/1 mixture of DMF/trimethyl orthoformate at room temperature. Several drops of concentrated HCl were added and the reaction was stirred until conversion to the benzimidazole by LCMS. Upon conversion by LCMS, the reaction was diluted with water and the orange precipitate was filtered off to afford 4-bromo-6-methyl-1H-benzo[d]imidazole as a crude orange solid (2.1 g, 75% yield). The solid was used without any further purification.
The synthetic route of 70733-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Vanderbilt University; Fesik, Steve; Waterson, Alex; Burns, Michael; Sun, Qi; Phan, Jason; Salovich, James M.; Abbott, Jason R.; Little, Andrew; (159 pag.)US10501421; (2019); B1;,
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