These common heterocyclic compound, 454-79-5, name is 2-Bromo-5-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Bromo-5-(trifluoromethyl)aniline
2.40 g of 2-bromo-5-trifluoromethyl-aniline and1.21 g of potassium ethylxanthate were dissolved in 35 ml of DMF solution, reacted under refluxing at 120 degree centigrade, and then reacted overnight under stirring at room temperature. TLC detection was performed and it was confirmed that raw materials no longer decreased, and the reaction was completed. The product was washed with 25 ml of dilute hydrochloric acid solution, organic layer was extracted, combined and dried, and column chromatography was carried out to obtain 1.70 g of an oily liquid (yield 72%). Mass spectrum MS of the compound: [M+H] 235.2.
The synthetic route of 2-Bromo-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DRIVINGFORCE THERAPEUTICS Co., Ltd.; YANG, Yongliang; (20 pag.)US2018/29979; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary