Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 452-74-4, name is 1-Bromo-2-fluoro-4-methylbenzene, A new synthetic method of this compound is introduced below., Product Details of 452-74-4
Step 3: Preparation of l-bromo-4-(bromomethyl)-2-fluorobenzene; To a room temperature solution of 4-bromo-3-fluorotoluene (10.6 g) in 150 mL of carbon tetrachloride were added benzoyl peroxide (100 mg ) and N-bromosuccinimide (10 g). The mixture was heated at 800C (with shine light) for 4 hours. The reaction mixture was cooled to 00C and filtered through celite, washed with hexanes and the solvent removed in vacuo. The crude material was purified by chromatography on SiO2 using hexanes to yield the title compound containing -30 % of 1- bromo-4-(dibromomethyl)-2-fluorobenzene as impurity.1H NMR (CD3COCD3) delta 7.66-7.10 (1 H, m), 7.42 (1 H, d), 7.29 (1 H, d), 4.66 (2 H, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2006/133559; (2006); A1;,
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