Electric Literature of 615-59-8, These common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(b) To a solution of 75 g (0.3 mol) of 2,5-dibromotoluene in 1 L of carbon tetrachloride was added 58.73 g (0.33 mol) of NBS and 50 mg of benzyl peroxide, and the resulting mixture was refluxed with stirring for 24 h. The mixture was cooled, and concentrated in vacuo. The residue was crystallized from hot methanol and washed with hexane to afford 54.5 g (55.7percent) of 2.5-dibromobenzyl bromide as a solid.
The synthetic route of 615-59-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sterling Winthrop Inc.; US5554620; (1996); A;,
Bromide – Wikipedia,
bromide – Wiktionary