Application of 1295502-53-2, A common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dried 50 mL three-necked flask, 25 mL of re-distilled toluene was added,Compound 2 (1. 05 g, 2 mmol),Pd (PPh3) 4 (46. 2 mg, 0.04 mmol) was added to the solution of 4,7-dimethoxy-5,6-dioxo benzo [c] [1,2,5] thiadiazole (221 mg, 0.67 mmol) Stirring dissolved; after nitrogen after 5 minutes,Using vacuum chestnut nitrogen 3 times;The solution was heated to 110 C for 72 hours. After cooling to room temperature, the solution was poured into 200 mL of methanol,The crude product was precipitated on a silica gel column using dichloromethane: petroleum ether (1: 1 by volume) as eluant,The red solid component was obtained as the object product (642 mg, yield 69%);
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; National Center for Nanoscience and Technology (NCNST); Wei, Zhixiang; Yuan, liu; (22 pag.)CN105315273; (2016); A;,
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