Application of 58971-11-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 58971-11-2 as follows.
To a solution of 3-bromophenethylamine (10.0 g, 50 mmol) in DCM (100 ml) containing TEA (8.36 g, 60 mmol, 1.2 eq.) cooled to 0 0C is added 2-chlorobenzoylchloride (8.75 g, 50 mmol, 1.0 eq.) portiowise. The resulting mixture is stirred at rt for 1 hr. Water (100 ml) is added to quench the reaction. The organic layer is collected, washed with water and brine, dried over sodium sulfate, and concentrated to give the title compound.
According to the analysis of related databases, 58971-11-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEUROGEN CORPORATION; WO2007/106349; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary