Adding a certain compound to certain chemical reactions, such as: 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-52-5, SDS of cas: 1435-52-5
General procedure: 6.11 1,4-Di(2-thienyl)-2-fluorobenzene (7k): Starting with 6 (100 mg, 0.39 mmol), Cs2CO3 (190 mg, 0.50 mmol), Pd(PPh3)4 (3 molpercent), 2-thienylboronic acid (49 mg, 0.39 mmol) and 1,4-dioxane (4 mL), 7k was isolated as a colorless solid (51 mg, 50percent). Mp 94-96 ¡ãC. 1H NMR (300 MHz, CDCl3): delta = 7.00-7.06 (m, 2H, ArH), 7.22-7.34 (m, 5H, ArH), 7.41-7.43 (m, 1H, ArH), 7.52-7.57 (m, 1H, ArH). 13C NMR (75.46 MHz, CDCl3): delta = 113.4 (d, J = 24.5 Hz, CH), 121.1 (d, J = 13.5 Hz, C), 121.8 (d, J = 3.1 Hz, CH), 123.8 (CH), 125.6 (CH), 125.8 (d, J = 4.5 Hz, CH), 126.3 (d, J = 7.1 Hz, CH), 127.8 (CH), 128.3 (CH), 129.0 (d, J = 4.2 Hz, CH), 134.9 (d, J = 9.4 Hz, C), 136.9 (d, J = 3.87 Hz, C), 142.6 (d, J = 2.9 Hz, C), 159.2 (d, JCF = 250.2 Hz, CF). 19F NMR (282.4 MHz, CDCl3): delta = -107.4 (CF). IR (ATR, cm-1): , 3074 (w), 2961 (w), 2854 (w), 1799 (w), 1606 (w), 1553 (w), 1483 (m), 1419 (m), 1354 (w), 1289 (w), 1259 (m), 1207 (w), 1135 (w), 1058 (m), 1015 (m), 945 (w), 866 (m), 805 (s), 692 (s), 630 (m), 579 (w), 550 (m), 528 (m). GC-MS (EI, 70 eV): m/z (percent) = 260 (100) [M+], 215 (12). HRMS (EI) calcd. for C14H9FS2 [M]+: 260.01242; found 260.01269.
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Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary